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Quantity Strength Unit Price Price Cart
30 Tablets Sinemet Carbidopa & Levodopa (10/100) $0.30 $8.99
90 Tablets Sinemet Carbidopa & Levodopa (10/100) $0.28 $24.99
30 Tablets Sinemet Carbidopa & Levodopa (25/100) $0.43 $12.99
90 Tablets Sinemet Carbidopa & Levodopa (25/100) $0.40 $35.99
30 Tablets Sinemet Carbidopa & Levodopa (50/200) CR $0.83 $24.99
90 Tablets Sinemet Carbidopa & Levodopa (50/200) CR $0.81 $72.99


Sinemet possess two pharmaceutical ingredients Levodopa and Carbidopa.  Both the ingredients are very effective to manage or decrease tremors and other symptoms of Parkinson disease. Carbidopa helps Levodopa to reach the brain and successfully overcome this problem in person having this problem.

 Nearly about more than one million people in the US are living with Parkinson's disease. It is a chronic and progressive disorder, meaning that symptoms continue and worsen over time The cause is unknown but it has been shown that it may occur due to degeneration of Dopamine (a type of nerve cells in involves the brain). There are various treatment options such as medication and surgery to manage its symptoms.

Carbidopa and Levodopa, is a first line drug that comes under the brand name of Sinemet, and which is prescribed round the clock for management and treatment of Parkinsonism disease.

What is the mechanism of action of Sinemet?

Administration of dopamine is ineffective in the management of Parkinson's disease as it does not cross the blood-brain barrier. However, Levodopa, the metabolic precursor of dopamine, does cross the blood-brain barrier, and subsequently converted to dopamine in the brain.

How to take Sinemet?

The tablet should be taken usually 3 to 4 times a day by mouth with a glass of water or through recommendation by your doctor upon medical condition of the patient. Take it without regard to food but avoids a high-protein diet as it decreases the amount of Levodopa in the blood. Avoid multivitamins and minerals. Taking the drug with iron can reduce the amount of this medication absorbed by the blood.

Who should not take this medicine?

If a person is taking drugs like Nonselective monoamine oxidase (MAO) inhibitors (e.g., selegiline HCl are contraindicated for use with SINEMET. It is also contraindicated in patients with known hypersensitivity to any component of this drug, and in patients with narrow-angle glaucoma.

What other may affect the activity of Sinemet?

Some medicine may interact with Sinemet, especially any of the following:

Avoid MAO Inhibitors (eg, Phenelzine) and Tricyclic antidepressants as it, high blood pressure may be a risk factor. Other drugs that may interfere with the activity of Sinemet includes Metoclopramide, blood pressure medicines, Rasagiline, or Selegiline, Butyrophenones, Isoniazid, Papaverine and Phenothiazines.

How to store this drug?

Store the drug at cool and dry place, away from intense heat and direct sunlight.

What are the possible side effects of Sinemet?

Adverse effects that occur in patients receiving SINEMET are those due to the central activity of dopamine. These reactions usually can be reduced by dosage reduction. The most common adverse effects are dyskinesias including, dystonic, and other involuntary movements, constipation; dizziness; drowsiness; dry mouth and headache.

What are the precautionary measures should be taken while using this medication?

Common side effects of Sinemet like Drowsiness, dizziness, or light-headedness may be worse if you take it with alcohol. Do not drive or perform other possibly unsafe tasks that need concentration. Slowly increase physical activity as your symptoms improve. Take the drug with extreme caution in condition of diabetes, pregnancy or breast feeding condition.



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