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Motilium

Motilium

Domperidone

Availability: In stock

$0.29
Quantity Strength Unit Price Price Cart
30 Tab Domperidone 10 mg $0.37 $10.99
90 Tab Domperidone 10 mg $0.29 $25.99

Details

Domperidone as the main constituent of Motilium helps in relieving nausea and vomiting and can be useful in treating that may occur due to many causes such as by taking medicines for Parkinson's disease, anti cancer chemotherapy, general anesthetics, and in migraine.

Motilium does not cross blood brain barrier but enhances the release of prolactin from pituitary, lowers the esophageal pressure and accelerate gastric emptying and prevents vomiting.

How Motilium acts?

Active ingredient in Motilium is Domperidone, which is a dopamine antagonist having anti emetic properties. Anti emetic effects of Motilium is due to a combination of gastrokinetic or peripheral effects and antagonism of dopamine receptors in chemorecptor trigger zone which lies outside the blood brain barrier.

Blockage of dopamine receptors causes the tightening of muscles at the entry to stomach and relaxing at the exit of stomach and thus increases the contraction of muscles in the stomach itself.

It will speed up the gastric emptying and prevents reflux that is regurgitation of stomach contents back into food pipe and helps in preventing vomiting and reduces bloating and feeling of fullness and sickness

Who should not take Motilium?

  • Contraindicated in hypersensitive patients to Motilium or its ingredients
  • Contraindicated in children and adolescents weighing less than 35kg
  • Contraindicated in moderate to severe hepatic impairment
  • Contraindicated in severe renal impairment
  • Contraindicated in patients with gastro-intestinal hemorrhage, mechanical obstruction or perforation
  • Contraindicated in patients with cardiac disease such as congestive heart failure
  • Contraindicated in pregnant and nursing ladies.


What are the drug interactions of Motilium?

  • Anti-arrhythmic drugs- Disopyradone, hydroquinidine, quinidine, amiodraone, dronedarone, sotalol
  • Anti-psychotic drugs- Haloperidol, pimozide, sertindole
  • Anti-depressant drugs- Citalopram, escitalopram
  • Antibiotics- Erythromycin, levofloxacin, moxifloxacin, spiramycin
  • Anti fungal drugs-Pentamidine
  • Anti malarial drugs-Lumefantrine, Halofantrine
  • Some gastro intestinal drugs- Cisapride, prucalopride
  • Antihistaminic drugs - Mizolastine, mequitazine
  • Anti cancer drugs-Vincamine, toremifene, vandetanib
  • Protease inhibitors
  • Macrolides - Clarythromycin, telithromycin
  • Azole antifungal drugs- Itraconazole, ketoconazole


How you should store Motilium?

Store the medicine in its original blister pack at a temperature below 250C.

How you should take Motilium?

  • Motilium 10mg tablet three times a day with maximum dose of 30mg per day should be taken orally before meals and should not exceed the treatment duration for more than one week.
  • Motilium should be taken at lowest effective dose in adults and children.


What should be done in case of Doses if-?

Missed Dose- Skip the missed dose and resume your usual dosing schedule but do not double the dose.

Over Dose- Overdose of Motilium leads to dry mouth, depression, agitation, convulsions, hypersensitivity, so take immediate medical consultation in case of overdose.

Gastric lavage and administration of activated charcoal may be useful in overdose of Motilium.

What would be the side effects of taking Motilium?

  • Dry mouth
  • Skin rashes
  • Diarrhea
  • Breast pain, breast tenderness
  • Anxiety
  • Headache


What precautions should be taken while getting Motilium?

  • Consume it before meals because after meals its absorption gets delayed.
  • Patients of above 60 years of age should take caution while taking Motilium.
  • Patients with kidney disorders should also take care while taking the medicine
  • Patients whose weight is lesser than 35kgs

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